Hi! I am a a postdoctoral researcher at the University of Oxford, in the Nuffield Dept. of Surgical Sciences. I am interested in cancer biology, with current focus on cancer bioinformatics. However, I love and and continue to be involved in projects involving cell and molecular biology, and I have had extensive research experience in the wet lab. Outside the lab, I dabble in fun personal projects involving a Raspberry Pi, baking and gardening.
PhD in Surgical Sciences (prostate cancer), 2014
University of Oxford
MS by Research in Cancer Biology, 2010
Indian Institute of Technology Madras
Jawaharlal Institute of Postgraduate Medical Education and Research
Identifying new mechanisms that underlie the complex process of metastasis is vital to combat this fatal step in prostate cancer (PCa) progression. Small non-coding RNAs are emerging as important regulators of tumor cell biology. Here we take an integrative approach to elucidate the contribution of microRNAs to metastatic progression, combining transcriptomic analysis with functional screens for migration and morphology. We developed high-content microscopy, high-throughput functional screens for migration and morphology in PCa cells using a microRNA library. RNA-Seq analysis of paired epithelial and mesenchymal PCa cells identified differential expression of 200 microRNAs. Data integration identified two microRNAs that inhibited migration, induced an epithelial-like morphology and were increased in epithelial PCa cells. An overrepresentation of the AAGUGC seed sequence was detected in all three datasets. Analysis of published datasets of patients with PCa identified microRNAs of clinical relevance. The integration of high-throughput functional and expression analyses identifies microRNAs with clinical significance that modulate metastatic behavior in PCa.